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In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is responsible for chemo resistance and metastasis. Clinically, the toxicity symptom of salinomycin in birds include feed refusal, muscular weakness, sternal recumbency, diarrhea, weight depression and death. Histopathologically, salinomycin induces severe myocardial and skeletal muscle lesions showing myocardial hyperemia, myocardial fiber degeneration and myocardial mitochondria damage. Salinomycin is the key compound in the pharmaceutical company Verastem's efforts to produce an anti-cancer-stem-cell drug.

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A) Boyden chamber migration assays of different cancer cell lines during treatment. MDA-MB-436, LLC and 4T1-luc cells were treated for 18 h with 10 μM, 0.5 μM and 0.5 μM doxorubicin or 0.05 μM, 0.5 μM and 0.05 μM salinomycin, respectively. 2019-02-14 · Objectives Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Methods Primary tumor-initiating salinomycin in the feed additive, premixtures and feedingstuffs.
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2019-11-13 · Moreover, salinomycin efficiently depresses the transcription of Twist1 which is fundamental for the salinomycin-mediated CSCs eradiation and migration/invasion restriction in UM cells.

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13 Nov 2019 Uveal melanoma (UM) is the most common primary intraocular tumor. Hepatic metastasis is the major and direct death-related reason in UM Treatment of 5 mg/kg salinomycin in mice implanted with SUM159 human breast cancer cells inhibits mammary tumor growth and induces increased epithelial 14 Feb 2019 Objectives Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on Salinomycin toxicity in turkeys has been reported on numerous occasions. Do not feed to turkeys. Clinically, the toxicity symptom of salinomycin in birds include Salinomycin by unknown from Flipkart.com. Only Genuine Products. 30 Day Replacement Guarantee.